Vector-peptide Conjugated Paclitaxel
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Vector-peptide Conjugated Paclitaxel Definition
A proprietary conjugate of paclitaxel with antineoplastic activity. Similar to the free drug, the paclitaxel moiety in vector-peptide conjugated paclitaxel binds to and stabilizes tubulin molecules, promoting assembly of microtubules and inhibiting tubulin disassembly which results in the inhibition of cell division. The Kunitz domain-derived vector-peptide carries the conjugated paclitaxel through the blood brain barrier (BBB), bypassing the transmembrane p-glycoprotein (P-gp) efflux pump, which may result in higher concentrations of paclitaxel in the brain parenchyma.
Vector-peptide Conjugated Paclitaxel Synonyms
Vector-peptide Conjugated Paclitaxel, Taxol-Angiopep Conjugate
Terms in Vector-peptide Conjugated Paclitaxel category
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