Vinca-Site Binding Agent
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Vinca-Site Binding Agent Definition
A class of anti-mitotic compounds that bind to the vinca site of the beta tubulin subunit, a region located within the middle domain of the tubulin structure and corresponding with a residue sequence approximating 177-215. The agent binds to the vinca site to produce a conformational change in the protofilament structure and at high concentrations, to induce the formation of spirals and crystal aggregates; these changes impair the polymerization of tubulin dimers and thereby, prevent the assembly of microtubules. The subsequent decrease in the amount of formed microtubules causes disassembly of the mitotic spindle resulting from instability of the structure during the mitotic interphase, eventually leading to cell cycle arrest and/or apoptosis. Vinca-site binding agents include natural compounds isolated from the periwinkle (Catharanthus roseus, formally, Vinca roseus) plant and synthetic compounds.
Vinca-Site Binding Agent Synonyms
Vinca-Domain Binding Agent, Vinca-Domain Binding Agents, Vinca-Site Binding Agent, Vinca-Site Binding Agents
Terms in Vinca-Site Binding Agent category
CemadotinCemadotin BaseCryptophycinCryptophycin 52E7389EC145Halichondrin BHemiasterlin Analog 7974SpongistatinTTI-237
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