Cancer Terms

Voltage-Dependent Anion Channel-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Transport Protein -> Ion Channel Protein -> Voltage-Dependent Anion Channel-1

Voltage-Dependent Anion Channel-1 Definition

Expressed in heart, liver, and skeletal muscle by human VDAC1 Gene (Mitochondrial Porin Family), ubiquitous 282-aa 31-kDa Voltage-Dependent Anion Channel-1 protein consists mainly of membrane-spanning beta-sheets that form a channel in the mitochondrial outer membrane and plasma membrane that adopts transmembrane voltage-dependent open/closed conformations and allows diffusion of small hydrophilic molecules. In response to apoptotic signal transduction, BCL2 proteins regulate cell death by controlling mitochondrial membrane permeability during apoptosis; BCLXL binds to and closes VDAC. Proapoptotic BAX and BAK accelerate VDAC opening, allowing cytochrome C to pass through VDAC, which activates death-driving proteolytic caspases. (NCI)

Voltage-Dependent Anion Channel-1 Synonyms

Voltage-Dependent Anion Channel-1, Outer Mitochondrial Membrane Protein Porin-1, Plasmalemmal Porin, Porin, Porin 31HL, Porin 31HM, VDAC-1, Voltage-Dependent Anion-Selective Channel Protein-1, hVDAC1

Terms in Voltage-Dependent Anion Channel-1 category



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