WNT1 Inducible Signaling Pathway Protein-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> WNT1 Inducible Signaling Pathway Protein-1

WNT1 Inducible Signaling Pathway Protein-1 Definition

Associated with cell survival and expressed in fibroblasts (high), heart, kidney, lung, pancreas, placenta, ovary, small intestine, and spleen by human WISP1 Gene (WISP/CCN/CTGF Family), 367-aa 40-kDa (precursor) and 280-aa isoforms of secreted WNT1 Inducible Signaling Pathway Protein 1 contain 4 conserved Cys-rich domains: a IGFBP domain, a VWFC domain, a TSP type-1 domain, and a CTCK domain. WISP1 up-regulates anti-apoptotic BCL-X(L) protein and attenuates p53-mediated apoptosis induced by DNA damage through activation of AKT kinase. WISP1 binds to, and may prevent the anti-proliferation activity of, decorin and biglycan, small leucine-rich connective tissue extracellular matrix proteoglycans. WISP1 may act as a downstream regulator in the WNT/Frizzled signaling pathway. (NCI)

WNT1 Inducible Signaling Pathway Protein-1 Synonyms

WNT1 Inducible Signaling Pathway Protein 1, WISP1, WISP1 Protein, WNT-1-Induced Secreted Protein

WNT1 Inducible Signaling Pathway Protein-1

WNT1 Inducible Signaling Pathway Protein-1 Definition

WNT1 Inducible Signaling Pathway Protein-1 Synonyms

Terms in WNT1 Inducible Signaling Pathway Protein-1 category