WRN Protein
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Gene Product ->
Protein ->
Protein Organized by Function ->
Enzyme ->
Hydrolase ->
Helicase ->
DNA Helicase ->
RecQ Helicase Family Protein -> WRN Protein
WRN Protein Definition
The WS gene encodes WRN, a 1,432-amino acid polypeptide. WRN is a member of the RecQ family of DNA helicases that unwind duplex DNA. It can also digest DNA exonucleolytically with 3'-5' polarity. WRN may facilitate pol d-mediated DNA replication and/or DNA repair and disruption of WRN-DNA polymerase delta interaction in WS cells may contribute to the S-phase defects and/or the unusual sensitivity to a limited number of DNA damaging agents. (Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4603-8)
WRN Protein Synonyms
WRN Protein, WRN, Werner Syndrome Protein
Terms in WRN Protein category
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