Cancer Terms

WRN Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Helicase -> DNA Helicase -> RecQ Helicase Family Protein -> WRN Protein

WRN Protein Definition

The WS gene encodes WRN, a 1,432-amino acid polypeptide. WRN is a member of the RecQ family of DNA helicases that unwind duplex DNA. It can also digest DNA exonucleolytically with 3'-5' polarity. WRN may facilitate pol d-mediated DNA replication and/or DNA repair and disruption of WRN-DNA polymerase delta interaction in WS cells may contribute to the S-phase defects and/or the unusual sensitivity to a limited number of DNA damaging agents. (Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4603-8)

WRN Protein Synonyms

WRN Protein, WRN, Werner Syndrome Protein

Terms in WRN Protein category



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