Wolf-Hirschhorn Syndrome Candidate-1 Protein

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Wolf-Hirschhorn Syndrome Candidate-1 Protein Definition

Encoded by human oncogene WHSC1 Gene, 1365-amino acid 152 kD Wolf-Hirschhorn Syndrome Candidate 1 Protein contains a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. WHSC1 is preferentially expressed in rapidly growing embryonic tissues, in a pattern corresponding to affected organs in WHS patients. The nature of the protein motifs and expression pattern suggest that WHSC1 is a good candidate responsible for many of the phenotypic features of WHS; a malformation syndrome associated with hemizygous deletion of the chromosome 4 distal short arm. (OMIM, Swiss-Prot, LocusLink, and NCI)

Wolf-Hirschhorn Syndrome Candidate-1 Protein Synonyms

Wolf-Hirschhorn Syndrome Candidate 1 Protein, MMSET Protein, Multiple Myeloma Set Domain Protein, NSD2 Protein, Nuclear Set Domain-Containing 2 Protein, WHSC1, WHSC1 Protein

Terms in Wolf-Hirschhorn Syndrome Candidate-1 Protein category

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