XL647
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XL647 Definition
An orally active receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This results in the inhibition of tumor growth and angiogenesis, and eventually leads to tumor regression.
XL647 Synonyms
XL647
Terms in XL647 category
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