Xeroderma Pigmentosum Complementation Group-A Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> DNA Repair Protein -> Xeroderma Pigmentosum Complementation Group-A Protein

Xeroderma Pigmentosum Complementation Group-A Protein Definition

DNA-Repair Protein Complementing XP-A Cells (XPA), the nuclear protein encoded by the XPA gene, has a zinc finger domain and is involved in the DNA excision repair pathway. XPA initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA complements the defect in xeroderma pigmentosum (XP) group A (XP-A), an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.

Xeroderma Pigmentosum Complementation Group-A Protein Synonyms

Xeroderma Pigmentosum Complementation Group A Protein, XPA, Xeroderma Pigmentosum Group A Complementing Protein

Terms in Xeroderma Pigmentosum Complementation Group-A Protein category

---

Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.