Zebularine
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DNA Methyltransferase Inhibitor -> Zebularine
Zebularine Definition
A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions.
Zebularine Synonyms
Zebularine, 1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone, 2-Pyrimidone-1-beta-D-riboside, Pyrimidin-2-one beta-Ribofuranoside
Terms in Zebularine category
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