Zinc Finger Protein-151
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Zinc Finger Protein-151 Definition
Encoded by human oncogene ZNF151 Gene (Kruppel Family) and highly expressed in brain and muscle, 803-amino acid 88 kD Zinc Finger Protein 151, similar to Z13 (mouse), contains an N-terminal BTB/POZ domain and thirteen C2H2 zinc finger domains connected by conserved H/C links. Predominantly cytoplasmic, ZNF151 may arrest growth (S/M) by activation of growth inhibitory genes. Associated with microtubules, ZNF151 may activate gene transcription in response to cytoskeletal changes. ZNF151 can transactivate cyclin D1 (CCND1,) alpha-2 integrin, and LDLR. ZNF151 interacts specifically with the HLH domain of MYC and NMYC. MYC interaction inhibits ZNF151 transactivation, induces ZNF151 nuclear sequestration, and overcomes ZNF151-induced growth arrest. (OMIM, Swiss-Prot, and NCI)
Zinc Finger Protein-151 Synonyms
Zinc Finger Protein 151, MIZ-1 Protein, MIZ17709, MYC-Interacting Zinc Finger Protein 1, ZNF151
Terms in Zinc Finger Protein-151 category
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