c-Myb Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> c-Myb Protein

c-Myb Protein Definition

Encoded by human MYB Gene as 6 alternative isoforms, 640 aa 72-kDa nuclear c-MYB protein is a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1.

c-Myb Protein Synonyms

Myb Proto-Oncogene Protein, MYB, c-Myb, c-Myb Protein

Terms in c-Myb Protein category

Myb Oncogene Protein