cAMP Responsive Element Binding Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> cAMP Responsive Element Binding Protein

cAMP Responsive Element Binding Protein Definition

Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)

cAMP Responsive Element Binding Protein Synonyms

cAMP Responsive Element Binding Protein, CRE Binding Protein, CREB, CREB Protein, Cyclic AMP Responsive Element Binding Protein

Terms in cAMP Responsive Element Binding Protein category

Forkhead Box C2
cAMP Responsive Element Binding Protein-1
cAMP Responsive Element Binding Protein-3
cAMP Responsive Element Binding Protein-4
cAMP Responsive Element Binding Protein-5