cAMP Responsive Element Binding Protein-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> cAMP Responsive Element Binding Protein -> cAMP Responsive Element Binding Protein-3

cAMP Responsive Element Binding Protein-3 Definition

Encoded by human CREB3 Gene (bZIP/CREB Family), ubiquitous 371-aa cAMP Responsive Element Binding Protein 3 is a conserved transcription factor that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters; possesses an acidic Glu-rich N-terminal transcription activation domain, a Ser-rich region, a central bZIP domain, and a Pro-rich C-terminal region; and interacts with conserved HCFC1 and OCT1. Cytoplasmic CREB3 is colocalized with ER-associated Calnexin. CREB3 and HSV VP16 protein bind the same HCFC1 site. CREB3-HCFC1 release permits VP16-induced transcription of HSV immediate-early genes by association with OCT1, stabilized by interaction with the interacting HCFC1 N- and C-termini. HCV core protein C terminus interacts with the CREB3 bZIP domain and prevents nuclear CREB3 dimer formation. (NCI)

cAMP Responsive Element Binding Protein-3 Synonyms

cAMP Responsive Element Binding Protein 3, Basic Leucine Zipper Protein, Basic Leucine Zipper Protein LZIP, CREB3, Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription Factor 1, Luman, Transcription Factor LZIP-Alpha

Terms in cAMP Responsive Element Binding Protein-3 category

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