Cancer Terms

hBRM

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> SWI2-SNF2 Family Protein -> hBRM

hBRM Definition

An ATPase subunit of the SWI/SNF enzyme, BRM belongs to the SNF2/RAD54 helicase family, contains a bromodomain, and is a co-activator for nuclear hormone receptors. BRM is a yeast transcription factor SWI2 homologue. Nuclear BRM is phosphorylated, excluded from condensed chromosomes, and strongly reduced during mitosis; phosphorylation does not disrupt the association with SNF5, but correlates with decreased affinity for the nuclear structure in early M-phase. SWI/SNF enzymes promote MyoD-mediated muscle differentiation by altering chromatin structure in promoter regions of differentiation-specific loci. (from SWISS-PROT P51531, OMIM 600014, and NCI)

hBRM Synonyms

hBRM, BRM Homolog, BRM/SNF2alpha, Human Brahma, Possible Global Transcription Activator SNF2L2, SNF2-Like 2, SNF2/SWI2 Homolog, SNF2L2, SNF2LA, SNF2alpha, SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 2, Smarca2, Sucrose Nonfermenting Homolog-Like 2

Terms in hBRM category



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