p21-Activated Kinase-6

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> p21-Activated Kinase-6

p21-Activated Kinase-6 Definition

p21-Activated Kinase 6, encoded by the PAK6 gene, shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. p21-Activated Kinase 6 was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The PAK6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. (from LocusLink)

p21-Activated Kinase-6 Synonyms

p21-Activated Kinase 6, EC 2.7.1.-, PAK-5, PAK-6, PAK6, Serine/Threonine-Protein Kinase PAK 6, p21(CDKN1A)-Activated Kinase 6, p21-Activated Protein Kinase 6

p21-Activated Kinase-6

p21-Activated Kinase-6 Definition

p21-Activated Kinase-6 Synonyms

Terms in p21-Activated Kinase-6 category