p300 CBP-Associated Factor
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Histone Acetylase -> p300 CBP-Associated Factor
p300 CBP-Associated Factor Definition
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation. p300/CBP-Associated Factor, encoded by the PCAF gene, displays in vivo binding activity with CBP and p300. This protein has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that it plays a direct role in transcriptional regulation. It also associates with NF-kappa-B p65. Protein kinase A regulates the transcriptional activity of NF-kappa-B by modulating its interaction with CPB/p300. (from LocusLink)
p300 CBP-Associated Factor Synonyms
p300/CBP-Associated Factor, CREBBP-Associated Factor, EC 2.3.1.-, Histone Acetylase PCAF, P/CAF, PCAF
Terms in p300 CBP-Associated Factor category
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