t 12 21 p13 q22
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Chromosomal Translocation -> t 12 21 p13 q22
t 12 21 p13 q22 Definition
A translocation between chromosomes 12 and 21 involved in TEL-AML1 oncogene formation. The translocation produces a chimeric gene encoding a protein consisting of the N-terminal HLH domain of the TEL ETS-like transcription factor fused with a nearly complete AML1 protein. t(12;21) is the most frequent translocation causing ALL, accounting for 20% of ALL cases.
t 12 21 p13 q22 Synonyms
t(12;21)(p13;q22)
Terms in t 12 21 p13 q22 category
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