t 12 21 p13 q22 TEL-AML1
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t 12 21 p13 q22 TEL-AML1 Definition
t(12;21) is a chromosomal translocation, involved in TEL-AML1 oncogene formation, that produces a chimeric gene encoding a protein consisting of the N-terminal HLH domain of the TEL ETS-like transcription factor fused with a nearly complete AML1 protein. t(12;21) is the most frequent translocation causing ALL, accounting for 20% of ALL cases.
t 12 21 p13 q22 TEL-AML1 Synonyms
t(12;21)(p13;q22)
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